Jantoven Advanced Patient Information

Generic name: warfarin [WAR-far-in]
Brand names: Coumadin, Jantoven
Drug class: Coumarins and indandiones

Medically reviewed by Drugs.com. Last updated on Nov 5, 2023.

Oral route(Tablet)

Warfarin can cause major or fatal bleeding. Regular monitoring of INR should be performed on all treated patients. Drugs, dietary changes, and other factors affect INR levels achieved with warfarin sodium therapy. Instruct patients about prevention measures to minimize risk of bleeding and to report signs and symptoms of bleeding .

Uses for Jantoven

Warfarin is used to prevent or treat blood clots, including deep venous thrombosis or pulmonary embolism. It is also used for blood clots that may be caused by certain heart conditions, open-heart surgery, or after a heart attack. Warfarin is an anticoagulant (blood thinner) that decreases the clotting ability of the blood.

This medicine is available only with your doctor's prescription.

Before using Jantoven

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of warfarin in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of warfarin in the elderly. However, elderly patients may require caution and an adjustment in the dose, especially those who are at risk of bleeding.

Breast Feeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Defibrotide
Tamoxifen

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Abametapir
Abciximab
Aceclofenac
Acemetacin
Acenocoumarol
Adagrasib
Adalimumab
Alefacept
Alipogene Tiparvovec
Allopurinol
Alteplase, Recombinant
Amiodarone
Amoxicillin
Ampicillin
Amtolmetin Guacil
Anagrelide
Anistreplase
Apalutamide
Apixaban
Asciminib
Aspirin
Atazanavir
Azithromycin
Bemiparin
Betrixaban
Bicalutamide
Bimekizumab-bkzx
Bivalirudin
Bromfenac
Bufexamac
Cabozantinib
Cangrelor
Cannabidiol
Cannabis
Capecitabine
Caplacizumab-yhdp
Capmatinib
Carbenicillin
Carboplatin
Cefadroxil
Cefdinir
Cefepime
Cefixime
Cefotaxime
Cefpodoxime
Ceftaroline Fosamil
Ceftazidime
Ceftibuten
Ceftizoxime
Celecoxib
Cephalexin
Cephalothin
Cephapirin
Cephradine
Ceritinib
Chamomile
Choline Salicylate
Cilostazol
Ciprofibrate
Ciprofloxacin
Citalopram
Clarithromycin
Clonixin
Clopidogrel
Cloxacillin
Cobicistat
Collagenase, Clostridium histolyticum
Curcumin
Cyclophosphamide
Dabigatran Etexilate
Dabrafenib
Daclatasvir
Dalteparin
Danaparoid
Dapsone
Darunavir
Dasabuvir
Deferasirox
Desvenlafaxine
Dexibuprofen
Dexketoprofen
Diclofenac
Dicloxacillin
Diflunisal
Dihydroartemisinin
Dipyridamole
Dipyrone
Doxifluridine
Doxorubicin
Doxorubicin Hydrochloride Liposome
Dronedarone
Drotrecogin Alfa
Droxicam
Duloxetine
Econazole
Edoxaban
Efavirenz
Elbasvir
Elvitegravir
Enoxacin
Enoxaparin
Entacapone
Enzalutamide
Epoprostenol
Eptifibatide
Erlotinib
Erythromycin
Escitalopram
Etodolac
Etofenamate
Etoposide
Etoricoxib
Etravirine
Felbinac
Fenofibrate
Fenofibric Acid
Fenoprofen
Fepradinol
Feprazone
Fish Oil
Floctafenine
Fluconazole
Flufenamic Acid
Fluorouracil
Fluoxetine
Flurbiprofen
Fluvoxamine
Fosnetupitant
Garlic
Gatifloxacin
Gemcitabine
Gemfibrozil
Gemifloxacin
Ginkgo
Glucagon
Grazoprevir
Ibrutinib
Ibuprofen
Iloprost
Imatinib
Indomethacin
Infliximab
Influenza Virus Vaccine
Inotersen
Itraconazole
Ivacaftor
Ivosidenib
Ketoconazole
Ketoprofen
Ketorolac
Ledipasvir
Leflunomide
Lepirudin
Letermovir
Levocarnitine
Levofloxacin
Levomilnacipran
Linezolid
Lomitapide
Lornoxicam
Loxoprofen
Lumiracoxib
Lycium
Mavacamten
Mechlorethamine
Meclofenamate
Mefenamic Acid
Megestrol
Meloxicam
Melphalan
Mercaptopurine
Methicillin
Methotrexate
Methylphenidate
Methyl Salicylate
Metronidazole
Miconazole
Milnacipran
Mirtazapine
Mitapivat
Morniflumate
Moxalactam
Moxifloxacin
Nabumetone
Nadroparin
Nafcillin
Nalidixic Acid
Nandrolone
Naproxen
Nepafenac
Netupitant
Niflumic Acid
Nilotinib
Nimesulide
Nimesulide Beta Cyclodextrin
Nintedanib
Nitisinone
Norfloxacin
Noscapine
Obeticholic Acid
Ofloxacin
Omadacycline
Ombitasvir
Omeprazole
Oritavancin
Orlistat
Oseltamivir
Oxacillin
Oxaliplatin
Oxandrolone
Oxaprozin
Oxyphenbutazone
Oxypurinol
Papaya
Parecoxib
Paritaprevir
Paroxetine
Peginterferon Alfa-2b
Penicillin G
Penicillin V
Pentosan Polysulfate Sodium
Phenindione
Phenobarbital
Phenprocoumon
Phenylbutazone
Piketoprofen
Piperacillin
Piracetam
Piroxicam
Pixantrone
Posaconazole
Pranoprofen
Prasugrel
Primidone
Procarbazine
Proglumetacin
Proguanil
Propyphenazone
Proquazone
Regorafenib
Reteplase, Recombinant
Ribavirin
Rivaroxaban
Rofecoxib
Ropinirole
Rosuvastatin
Roxithromycin
Rucaparib
Sarecycline
Secnidazole
Selexipag
Selumetinib
Sertraline
Simeprevir
Simvastatin
Sitaxsentan
Sofosbuvir
Sparsentan
St John's Wort
Streptokinase
Sulfamethoxazole
Sulfisoxazole
Sulindac
Sultamicillin
Tan-Shen
Tegafur
Telithromycin
Tenecteplase
Tenoxicam
Teriflunomide
Testosterone
Tiaprofenic Acid
Ticagrelor
Ticarcillin
Ticlopidine
Tinzaparin
Tirofiban
Tirzepatide
Tocophersolan
Tolfenamic Acid
Tolmetin
Torsemide
Trazodone
Treprostinil
Turmeric
Urokinase
Ustekinumab
Valdecoxib
Valproic Acid
Velpatasvir
Venlafaxine
Vilazodone
Vincristine
Vincristine Sulfate Liposome
Vindesine
Vorapaxar
Voriconazole
Vortioxetine
Voxilaprevir

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

Cranberry Juice
Pomegranate
Tobacco

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

Avocado
Black Tea
Enteral Nutrition
Green Tea
High Protein Food
Noni Juice
Soybean
Vitamin K Containing Food

Proper use of Jantoven

Take this medicine only as directed by your doctor. Your dose may need to be changed several times in order to find out what works best for you. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered.

This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Carefully follow your doctor's instructions about any special diet. This medicine works best when you eat about the same amount of vitamin K in your food every day. Tell your doctor before changing your diet. Avoid big changes in how much vitamin K you eat. Some foods that have a high amount of vitamin K are asparagus, broccoli, brussels sprouts, cabbage, green leafy vegetables (such as collards, turnip greens, mustard greens, spinach, and salad greens), plums, rhubarb, and certain vegetable oils (such as soybean oil and canola oil).

You may take the tablets on a full or empty stomach.

Do not drink grapefruit juice while you are using this medicine. Grapefruit juice may change the amount of this medicine that is absorbed in the body.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (tablets):
- For prevention or treatment of blood clots:
  - Adult—At first, 2 to 5 milligrams (mg) as a single dose once per day. Your doctor may adjust your dose if needed. However, the dose is usually not more than 10 mg per day.
  - Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Jantoven dosage information

Precautions while using Jantoven

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood tests, such as an INR, are needed to check for proper dosage and unwanted side effects. Be sure to keep all appointments.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant during treatment and for at least 1 month after the last dose. If you think you have become pregnant while using this medicine, tell your doctor right away.

Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery or medical tests.

Check with your doctor immediately if you have diarrhea, fever, or any symptoms of an infection.

This medicine may cause skin necrosis or gangrene. Call your doctor right away if you have pain, a color change, or a temperature change to any area of your body. Call your doctor right away if you have pain in your toes and they look purple or dark in color. These could be signs of a serious medical problem.

Calciphylaxis or calcium uremic arteriolopathy may occur in patients with or without end-stage kidney disease. Tell your doctor right away if you have purplish red, net-like, blotchy spots on the skin.

Warfarin may increase your risk of having kidney problems, including acute kidney injury. Check with your doctor right away if you have blood in the urine, decreased urine output, muscle twitching, nausea, rapid weight gain, seizures, stupor, swelling of the face, ankles, or hands, or unusual tiredness or weakness.

This medicine may increase your chance of bleeding. Check with your doctor right away if you notice any unusual bleeding or bruising, black, tarry stools, blood in the urine or stools, or pinpoint red spots on your skin. Avoid picking your nose. If you need to blow your nose, blow it gently.

Be careful when using a regular toothbrush, dental floss, or toothpick. Your medical doctor, dentist, or nurse may recommend other ways to clean your teeth and gums. Check with your medical doctor before having any dental work done.

Be careful not to cut yourself when you are using sharp objects, such as a safety razor or fingernail or toenail cutters. Avoid contact sports or other situations where bruising or injury could occur.

It is recommended that you carry identification that says you are using warfarin. If you have any questions about what kind of identification to carry, check with your doctor.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription medicines, nonprescription (over-the-counter [OTC]) medicines, and herbal or vitamin supplements.

Side Effects of Jantoven

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

Bleeding gums
blood in the urine
bloody stools
blurred vision
burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
chest pain or discomfort
confusion
coughing up blood
difficulty with breathing or swallowing
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
excessive bruising
headache
increased menstrual flow or vagin*l bleeding
nosebleeds
paralysis
peeling of the skin
prolonged bleeding from cuts
red or black, tarry stools
red or dark brown urine
stomach pain with cramping
sweating
unexplained swelling
unusual tiredness or weakness

Rare

Arm, back, or jaw pain
blue-green to black skin discoloration
blue or purple toes
change in consciousness
chest tightness or heaviness
chills
clay-colored stools
diarrhea
dizziness
fainting or loss of consciousness
fast or irregular breathing
fast or irregular heartbeat
fever
itching or skin rash
light-colored stools
loss of appetite
nausea and vomiting
pain in the toes
pain, redness, or sloughing of the skin
pale skin
purplish red, net-like, blotchy spots on the skin
skin blisters
small red or purple spots on the skin
stomach pain
swelling of the eyes or eyelids
troubled breathing with exertion
unpleasant breath odor
unusual bleeding or bruising
upper right stomach pain
vomiting of blood
yellow eyes and skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Joint pain
muscle pain

Rare

Bloated
change in taste, or bad, unusual, or unpleasant (after) taste
cold intolerance
excess air or gas in the stomach or intestines
full feeling
general feeling of discomfort or illness
hair loss or thinning of the hair
hives or welts
lack or loss of strength
pain
passing gas
red, sore, or itching skin
sores, welting, or blisters
unusual drowsiness, dullness, or feeling of sluggishness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Jantoven side effects (more detail)

Commonly used brand name(s)

In the U.S.

Coumadin
Jantoven

Available Dosage Forms:

Tablet

Therapeutic Class: Anticoagulant

Chemical Class: Coumarin (class)

Frequently asked questions

What is the antidote for warfarin?
Is warfarin used as rat poison?
Does Feverfew interact with any drugs?
Why does warfarin cause purple toe syndrome?
Does cranberry juice help prevent a UTI?
Why are Warfarin tablets color-coded?
Is your blood really thinner with warfarin?

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Jantoven Advanced Patient Information - Drugs.com (2024)

Uses for Jantoven

Before using Jantoven

Allergies

Pediatric

Geriatric

Breast Feeding

Interactions with Medicines

Interactions with Food/Tobacco/Alcohol

Other Medical Problems

Related/similar drugs

Proper use of Jantoven

Dosing

Missed Dose

Storage

Precautions while using Jantoven

Side Effects of Jantoven

Commonly used brand name(s)

Frequently asked questions

More about Jantoven (warfarin)

Patient resources

Other brands

Professional resources

Other brands

Related treatment guides

Further information

References